Male infertility, causes, diagnosis and modern treatment
Pathological infertility factors are 10% caused by women and men, but by 50% caused by men, knowing that some men give birth despite the pathological changes in sperm, but half of the sterile men diagnose a clinically recognized cause through traditional semen analysis.
During the past five centuries, semen analysis was one of the basic analyzes in the diagnosis of male infertility, but some fundamental changes have developed the susceptibility of these analyzes to contribute to the diagnosis of reproductive and reproductive capacity clinically in men, especially through the discovery of infection in the semen and sperm in all its forms as a basic factor Partially or totally causing male infertility, now new diagnostic methods with high sensitivity and specificity have been discovered to measure the efficacy of Total Antioxidative Sperm Capacity and the ratio of reactive oxygen type in semen (Reactive Oxy). gen Species) and the percentage of breaking DNA strands in sperm (DNA Fragmentation) and through recent clinical studies, there were additional major factors causing infertility as well, but after treatment and diagnosis for three months with antioxidants, the rate of success of spontaneous fertilization or artificial insemination increased fivefold. Compared to those who were not treated with antioxidants despite the diagnosis of the aforementioned oxidative stress in their semen, knowing that the normal ratio of reactive oxygen in the semen is (1.5 x 10 ^ 4 cpm / 20 millions / sperm / ml).
Several recent clinical studies have evaluated the effectiveness and reasons for using therapeutic antioxidants, especially vitamin C, vitamin E, zinc metal, selenium salt, folic acid, and carnitine, that they lead to improved fertility in sterile men, as they have proven, after consuming these antagonists, for a period of not less than three months That the amount, movement, vitality, and effectiveness of fertile sperm in their semen have improved and increased to high levels, crowning the success of fertilization naturally and automatically, as well as in the case of submitting to artificial insemination (ART) among those who have a significant decrease in the number of sperm, especially What is under the millionth of a millimeter in the semen, as this led to a noticeable rise in the success rate of this vaccination (ART) and also led to a rise in the rate of birth rate to four times what it was before the treatment mentioned with these antioxidants.
It is worth noting that in the event of a high rate of fragmentation and fracture in the semen DNA, the vitality of these animals deteriorates in the transmission of parental genetic information, as well as in the physiology of the fetus as this may pathologically affect the safety of sperm chromatin (the chromosome part in the nucleus of the sperm cell) Which plays a major role in fertilization of the egg and the formation of the fetus. Therefore, measuring the percentage of DNA breakage and breakage in the sperm is laboratory. It is an important indicator for the diagnosis and treatment of male infertility, as the clinical statistics of these men who were diagnosed with it previously showed fracture. The DNA in their sperm and treated with antioxidants has improved the rate of spontaneous fertilization and their artificial insemination.
As we mentioned earlier, the perfection of chromatin in the nucleus of the sperm cell (Sperm chromatein Integrity) is of vital importance in two basic cases:
The first is the integrated and good growth of the fetus.
- The second is the transfer of genetic patriarchal information, because sperm chromatin is fully integrated with the protein of the cell nucleus of the sperm to be in the nucleus (protamine). Its high density in the sperm’s nucleus protects its DNA from breakage and hence its damages to fertilization.
The factors that lead to the oxidative stress causing this damage and breakdown in the DNA in the base of the DNA or its individual or double strands are:
Undergoing chemotherapy due to a cancerous disease in the body.
- The incidence of chronic bacterial and acute prostate infections, leading to a high percentage of leukocytes in the semen.
There are two laboratory methods to detect this with a measure of the degree of damage or breakage in the strands of DNA:
Sperm chromatin assay (SCSA) method.
DUTP assay method.
In the conclusion of this matter, the discovery of the method of osteoporosis by means of diagnosing pathogenic proteins in sperm of all kinds in the last ten years led to the knowledge of those mutilated, incomplete or suicidal ones that negatively affect fertilization and reproduction, especially in the event of its formation and secretion in abundance, as well as those that lead to degradation The movement of sperm, to its death, or to its formation or stunted growth also causes sterility, knowing that these modern laboratory methods have sensitive technology and high diagnostic specificity by which we can also discover and diagnose infertility factors for sub-cellular parts in For sperm also causing infertility and these are the ones that gave way to the treatment of infertility that was previously not possible and its cause was vague, especially by modern and effective antioxidants and for a period ranging between three to six months compared to treatments before these laboratory discoveries, whether by antagonists For oxidation, hormonal or artificial insemination after the diagnosis of these mutilated sperms by the above-mentioned laboratory method.
And last, but not least, the analysis of the seborrheic seminal fluid is still the distinguishing method, but at the present time it is no longer the only diagnostic method for the diagnosis of vague male infertility factors, which we can only diagnose through new and modern clinical laboratory methods that have been deepened into the sub-cell parts of the animal Sperm and now we can measure the rate of DNA damage in the sperm due to the oxidative effort in it and also we can at the present time measure the efficiency and capacity of the general sperm antioxidant (TAC). These diagnostic methods have now brought us to the knowledge of the additional main causes leading to male infertility and led us to reach with accurate and therapeutic success for these reasons which were before the discovery of these accurate, sensitive and highly diagnostic laboratory diagnostic methods insufficient to improve fertilization among these people.